Endocrine Abstracts

Context: Recent studies showed a high prevalence of anxiety and depressive symptoms in patients with primary hyperaldosteronism (PA). A cross-sectional analysis suggested only minor improvement following adrenalectomy (ADX) and mineralocorticoidreceptor antagonist (MRA) therapy.Objective: Our aim was to determine the course of anxiety and depression in untreated patients.Design: We investigated 15 patients with PA at time of diagno...

Obesity is characterized by an increase of endocannabinoid circulating levels as anandamide (AEA) and 2-arachidonoyl-glycerol (2AG). Whether these lipids represent a biomarker of dysmetabolism or merely reflect the fat mass spill-over is still unclear. After generating rigorous, gender specific, plasma reference intervals by 2D-liquid chromatography-tandem mass spectrometry, we defined the 97.5thcentile of endocannabinoid distribution in the normal population as the cut-off ab...

Introduction: Medical specialization model in Spain is carried out through specialized health training, through the residency program. Residents are a key element for the proper functioning of today’s National Health System. The aim of the study is to analyze, by an anonymous survey, the opinion of three aspects among final-year residents in Endocrinology and Nutrition (E&N): self-assessment of the knowledge acquired, working prospects, care and training consequences ...

Introduction: Parathyroid tumors are the most common (90%) and usually the first manifestation feature of MEN1 syndrome. The occurrence of anterior pituitary tumors in MEN1 syndrome may range between 10% and 60%. Pituitary involvement includes the initial manifestation of MEN1 syndrome in 10% to 25% of individuals and usually show more aggressive behavior; 20% secrete prolactin, fewer than 10% secrete GH, 5% secrete ACTH, and the remainder appear to ...

Objective: Cushing’s disease (CD) accounts for approximately 80% of cases of Cushing’s syndrome. Diagnosis of CD is difficult, it is carried out with a screening test and confirmation test. The aim of this study is to describe the diagnostic results of the different diagnostic tests used in the diagnosis of CD in our environment.Patients and methods: Retrospective descriptive study of patients with CD. We included all patients diagnosed with CD...

Introduction: Although meningiomas often occurs in parasellar regions such as the tuberculum sellae, olfactory groove, and sphenoid wing, pure intrasellar meningiomas are extremely rare. Patients usually present with gradual visual deterioration secondary to compression of the optic apparatus. Obtaining a correct preoperative diagnosis will likely require a thorough clinical assessment including neuroimaging and endocrine studies.Case report: A 56 year-o...

Estrogen-producing adrenal gland tumors (EPAGT) are extremely rare, accounting for only 1–2% of all adrenal tumors. They are most commonly observed in men or in children, and are unusual in women. They are almost always malignant even if they seem benign at presentation, and most of them have a poor prognosis. We present a case of a 71-year-old man with painful bilateral gynecomastia, without galactorrhea, over 4 months. Markedly elevated plasma estradiol levels were foun...

Introduction: The prevalence of pituitary thyrotropin secreting tumors (TSH-omas) is 1-2 cases per million inhabitants, most of them being macroadenomas. The differential diagnosis may be challenging, especially for microadenomas.Case Report: A 50-year-old male was observed at the endocrinology department with multinodular goiter. He noticed progressive neck enlargement over the previous months but denied other complaints. There was no family history of ...

Introduction: Hypocalcaemia is a potential post-thyroidectomy complication. Patients with previous Roux-en-Y Gastric Bypass (RYGBP) are at increased risk of symptomatic hypocalcaemia refractory to treatment. This complication is rare and there is not consensus on how to act.Clinic case: Female with 34 years old, with a history of Obesity (BMI 45.7 kg/m2), submitted to RYGBP in 2013, with a total loss of 47 kg (current BMI 27.3 kg/m2...

Introduction: Clinical inertia applied to type2 Diabetes Mellitus (T2DM) treatment, is defined as a lack of treatment’s intensification of patients who are not in HbA1c target. Clinical inertia leads to a postponement of new therapeutic introduction, with all complications associated with a poor metabolic control. In Portugal there are only studies that show good or poor metabolic control but do not mention clinician’s attitude towards these values. Recently publishe...